RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.

Product information

CAS Number: 2488788-52-7

Molecular Weight: 499.91

Formula: C22H25ClF3N5O3

Chemical Name: N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-2-chloro-6-(4-methoxyoxane-4-carbonyl)-5H, 6H, 7H-pyrrolo[3, 4-d]pyrimidin-4-amine

Smiles: COC1(CCOCC1)C(=O)N1CC2=NC(Cl)=NC(N[C@H](C)C3C=C(N)C=C(C=3)C(F)(F)F)=C2C1

InChiKey: HOBOGRTXXDLZIB-GFCCVEGCSA-N

InChi: InChI=1S/C22H25ClF3N5O3/c1-12(13-7-14(22(24,25)26)9-15(27)8-13)28-18-16-10-31(11-17(16)29-20(23)30-18)19(32)21(33-2)3-5-34-6-4-21/h7-9,12H,3-6,10-11,27H2,1-2H3,(H,28,29,30)/t12-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (250.05 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro.

In Vivo:

RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models.

Products are for research use only. Not for human use.