TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM.

Product information

CAS Number: 667411-04-3

Molecular Weight: 355.77

Formula: C19H14ClNO4

Synonym:

TRPM4-IN-2

TRPM4 IN-2

Chemical Name: 4-chloro-2-(2-(naphthalen-1-yloxy)acetamido)benzoic acid

Smiles: OC(=O)C1=CC=C(Cl)C=C1NC(=O)COC1=CC=CC2=CC=CC=C21

InChiKey: OKFVCWAYHJMQFA-UHFFFAOYSA-N

InChi: InChI=1S/C19H14ClNO4/c20-13-8-9-15(19(23)24)16(10-13)21-18(22)11-25-17-7-3-5-12-4-1-2-6-14(12)17/h1-10H,11H2,(H,21,22)(H,23,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Borgström A, Hauert B, Kappel S, Zoni E, Kiener M, Stokłosa P, Baur R, Spahn M, Kruithof-de Julio M, Peinelt C. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665. doi: 10.1016/j.jmb.2020.09.024. Epub 2020 Oct 12. PMID: 33058873.
2. Stokłosa P, Borgström A, Hauert B, Baur R, Peinelt C. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400. doi: 10.3390/cancers13215400. PMID: 34771564; PMCID: PMC8582472.

Products are for research use only. Not for human use.