VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation.

Product information

CAS Number: 312611-92-0

Molecular Weight: 287.36

Formula: C16H21N3O2

Synonym:

VK-28

VK 28

Chemical Name: 5-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)quinolin-8-ol

Smiles: OC1=CC=C(CN2CCN(CCO)CC2)C2=CC=CN=C12

InChiKey: XIXFNVDWEWCEOI-UHFFFAOYSA-N

InChi: InChI=1S/C16H21N3O2/c20-11-10-18-6-8-19(9-7-18)12-13-3-4-15(21)16-14(13)2-1-5-17-16/h1-5,20-21H,6-12H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Li Q, Wan J, Lan X, Han X, Wang Z, Wang J. Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 2017 Sep;37(9):3110-3123. doi: 10.1177/0271678X17709186. Epub 2017 May 23. PMID: 28534662; PMCID: PMC5584702.
2. Shachar DB, Kahana N, Kampel V, Warshawsky A, Youdim MB. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. Neuropharmacology. 2004 Feb;46(2):254-63. doi: 10.1016/j.neuropharm.2003.09.005. PMID: 14680763.
3. Youdim MB, Fridkin M, Zheng H. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases. Mech Ageing Dev. 2005 Feb;126(2):317-26. doi: 10.1016/j.mad.2004.08.023. PMID: 15621213.
4. Bandyopadhyay S, Huang X, Cho H, Greig NH, Youdim MB, Rogers JT. Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator. J Neural Transm Suppl. 2006;(71):237-47. doi: 10.1007/978-3-211-33328-0_25. PMID: 17447434.
5. Youdim MB, Stephenson G, Ben Shachar D. Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. Ann N Y Acad Sci. 2004 Mar;1012:306-25. doi: 10.1196/annals.1306.025. PMID: 15105275.

Products are for research use only. Not for human use.