NPY2-R (D42) Polyclonal Antibody

Catalogue Numbers:BS2818-50, BS2818-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P49146

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: NPY2-R is a member of the Gprotein-coupled receptor super-family, and like other members has seven putative transmembrane domains. However, NPY2-R gene consists of two exons, unlike the contiguous structure of other G-protein-coupled receptor genes. NPY2-R shares a 31% sequence identity with NPY1-R. NPY2-R is expressed in the presynaptic membranes of the central nervous system, and to a lesser extent the peripheral nervous system. NPY2-R associates (from highest to lowest affinity) with carboxyl terminals of unphosphorylate Peptide YY (PYY) (phosphorylation of PYY greatly reduces its binding affinity),NPY, and Pancreatic Peptide. Depending on the cell type, NPY2-R couples with different G proteins, which act as different second messengers. NPY2-R reduces the effects of depolarization, calcium ion currents in arterial smooth muscle by through association with NPY.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 43 kDa

Specificity: NPY2-R (D42) polyclonal antibody detects endogenous levels of NPY2-R protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: Neuropeptide Y receptor type 2; NPY2-R; NPY-Y2 receptor; Y2 receptor; NPY2R

Immunogen: Synthetic peptide, corresponding to amino acids 30-80 of Human NPY2-R.

Conjugate: Unconjugated

Modification: Unmodified