Delivery 7 - 14 days

L-Ornithine-L-Aspartate (LOLA) supports healthy nitrogen metabolism by promoting the natural detoxification of ammonia through the urea cycle and glutamine synthesis pathways.* By providing key amino acids, LOLA helps maintain liver function, ammonia clearance, and metabolic balance, especially during times of increased nitrogen stress. Each serving delivers 3 grams of clinically relevant LOLA in a versatile powdered form.

L-ornithine-L-aspartate supports liver function, and can help convert ammonia to urea and glutamine.

• L-Ornithine activates carbamoyl phosphate synthetase, the rate-limiting enzyme of the urea cycle, enhancing the conversion of ammonia to urea in periportal hepatocytes for excretion.*[1]
• L-Aspartate serves as a substrate in transamination reactions and contributes to glutamine synthesis, aiding in ammonia removal via non-urea pathways.*[3]
• Glutamine Synthetase Activation in perivenous hepatocytes, skeletal muscle, and brain tissue facilitates an additional mechanism for reducing circulating ammonia.*[3]
• Clinical Research supports the use of oral LOLA in improving ammonia metabolism and mental state, especially in individuals with hepatic metabolic burden.*[4]
• Meta-Analysis Findings indicate that LOLA supplementation significantly supports detoxification pathways.*[4,5]

Directions for use

As a food supplement, 1 rounded teaspoon daily.