Scarce on the market with no other examples available. An early Michigan medical journal complete with both original published research, peer review, etc., plus news from around the global medical community, exposure of quackery and fraud, etc., 

Extensive content related to syphilis and gonorrhea; opium addiction; a controversy involving quinine fraud; diphtheria; plus loads of fascinating content on blood-letting, blood-drinking, etc. 

Brodie, William [ed.] and J. J. Mulheron and A. B. Lyons [Assoc. Eds.]. The Therapeutic Gazette. A Monthly Journal Devoted to Therapeutics and to the Introduction of New Therapeutical Agents. January to December, 1883. Detroit. George S. Davis. Medical Publisher. 528pp.

Contents include: Psychoses with Cases to Illustrated Treatment by John J. Caldwell; Menthol and Chlor-Anodyne for Relieving the Pain of Neuralgia - Nine Cases by F. E. Stewart; Treatment of Catarrh of the Respiratory Apparatus; Effects of Various Medicines on the Secretion of Milk; A History of Three Grains of Morphia Sulphate [Morphine]; Hoang-Nan - Untoward Effects of its Use in a Case of Cancer; Prevention of Small Pox; Warm Bullock's Blood for Anemic Females; Methods of Overcoming Rigidity of the Os Uteri; Bowel Obstructions; The Anti-Malarial Zone by A. Comstock; Notes on Pancreatin; Compound Fluid Extract Sarza Pseudo-China; Alcohol in Health by C. Barlow; Poisoning by Damiana and Recovery by W. H. Bentley; Kolpoperineoplasty by William Fahy; Treatment of Gonorrhea with Oxygenated Water; Hypermanganate of Patassium in the Treatment of Snake Bites; Quackery and Quacks: Emmenagogues; Effects of Famine on the Public Health; Revival of Blood-Letting as a Therapeutic; Treatment of Syphilis; Treatment of Venereal Warts; Cortex Peruvianae by Linnaeus B. Anderson; An Appliance for a Broken Nose [Illustrated]; The Screw Worn, Alcohol and Opium; Sabbatia Campestris; The Opium Habit and Alcohol - Veratrum Viride in Opium Poisoning; Coca in the Opium Habit [Cocaine]; Market Flooded with Short-Weight Quinine Pills [Series]; Tincture of Cobweb in Treatment of Malarial Fevers; Sulphate of Quinine - A Brief History of its Physiological Properties by Linnaeus B. Anderson; Snake Poison; Hot Water Irrigations; Exposure of Medical Fraud; Medical College Commencements [Detroit Medical College]; The Blood Diet for Delicate Children; Extensive Content on Diptheria; What is Wrong with Our Emmenegogues? by Theo. L. Hatch; Fracture Splints for Humerus by S. Hubbell [Illustrated]; McDade's Formula for Syphilis; On Hydrotherapeutics; On the Removal of Tape-Worms; Vaccination - How it is Sometimes Condemned; Cocaine to Assuage Thirst [Coca]; Lime-Juice as an Anaphrodisiac; A New Use for the Condom; A Case of True Eastern Leprosy; Pop-Corn a New Remedy for the Vomiting of Pregnancy; Cascara Amarga and Berberis Aquifolium in Secondary and Tertiary Syphilis by W. H. Bentley; Bacillus Tuberculosis; French Journalism and American Quackery; Medical Bravery; The Rational Treatment of Gonorrhea; Cannabis Indica as a Remedy for Menorrhagia; Therapeutic Novelties; The Contagion of Gonorrhea; Druggists versus Physicians and Physicians versus the Code of Ethics; Treating Sexual Exhaustion with Cactus Grandifolia; Treatment of Syphilis with Cascara Amarga; Extensive on Jamaican Dogwood; Treating Opium Addiction with Erythroxylon Coca [Cocaine]; The Treatment of Hysteria; Kava Kava; The Therapeutic Use of Drinking Hot Water; The Beef Tea Fallacy; etc. etc. etc. 

Good condition in original heavily rubbed half leather, very solid but through leather and cloth at various points. Textually clean, crisp, and very usable.  A rare survivor. Signed by W. A. McDowell M.D., a traveling homeopathic practitioner who worked in Louisville KY, New Orleans LA, Rockford IL, Scranton PA, Sutton NE, etc.